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KMID : 0606920060140030152
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Biomolecules & Therapeutics
2006 Volume.14 No. 3 p.152 ~ p.159
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Effects of Static Magnetic Fields on Phagocytic Activity of Murine Peritoneal Macrophages
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Eun Jae-Soon
Ko Dae-Woong
Jeon Yong-Keun
Lee Kyung-A
Park Hoon
Ma Tian-Ze
Kim Min-Gul
Kwak Yong-Geun
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Abstract
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Electro-magnetic fields and static magnetic fields generated from diverse home/environmental sources have been reported that these could make harmful effects on the human health such as suppression of immunity and tumorigenesis. However, the mechanisms for the biologic effects of electro-magnetic fields or static magnetic fields are still remained unclear. In this study, we examined the in vitro effects of static magnetic fields (SMF) on murine peritoneal macrophages. The cells were exposed in vitro to SMF of 150~250 or 350~450 G in 5 % CO2-incubator. The phagocytic activity of murine peritoneal macrophages was inhibited under exposure to SMF. In order to provide a more complete picture of molecular mechanism for the biological effect of SMF, we compared the levels of total proteins from macrophages with or without exposure to SMF using quantitative proteomic analysis. Proteins which were differentially expressed in macrophages exposed to SMF compared with non-exposed macrophages, were identified. Among them, the levels of trypsinogen 16, lactose-binding lectin Mac-2, galactoside-binding lectin, actin-like (Put. β-actin, vimentin) and electron transferring flavoprotein beta polypeptide were enhanced under exposure to SMF. These results suggest that SMF can affect the phagocytic activity of macrophages via diverse mechanisms.
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KEYWORD
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Static magnetic fields, Macrophages, Phagocytic activity
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